Our team continues to improve this workflow and incorporate it into more of our evolutionary efforts.Although nature selected these proteins to perform their native functions, many also have promiscuous capabilities that are not used in the natural setting but that can fuel future functional evolution.We use this diversity of natural heme proteins and their non-natural promiscuous functions as the basis for generating new enzymes in the laboratory.We use directed evolution to create new enzymes that catalyze non-biological reactions with high efficiencies and selectivities.
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